I3C Indole-3-carbinol stands alone as the most well-studied natural estrogen modulator. Found in cruciferous vegetables such as cabbage, cauliflower and broccoli, I3C has proven effects against hormone-related cancers.
I3C may be an important tool against environmentally-caused cancer because it can block dioxin from entering cells. Dioxin is a chlorine chemical, known as the most toxic chemical ever created-so toxic it is measured in parts per trillion. The main source of it for most people is meat and dairy products. Popular fast foods such as McDonald’s Big Macs® have been found to contain metabolites of dioxin. Dioxin is suspected as a cause (or contributing cause) of breast, prostate, lymphoma and lung cancers.
I3C comes to the rescue by its ability to compete with dioxin for entry into cells. The same receptors, or doorways, that allow estrogen and dioxin into cells, allow I3C as well. When I3C and dioxin are put together with cells, I3C keeps some of the dioxin out by physically blocking the harmful chlorine chemical. This same mechanism also protects cells from strong estrogen that can promote cancer growth.
A recent study shows that treatment with I3C can reverse precancerous conditions of the cervix in humans. I3C may also protect smokers. When I3C was given to rats forced to ingest smoke, DNA damage was reduced over 50% in lungs and trachea, and 65% in the bladder. It also inhibits heterocyclic amines, dangerous carcinogens that form when meat is cooked. One study showed that I3C was up to 95% effective in inhibiting carcinogens. (Note: the recommended dose for I3C is 400 mg for most women and 600 mg for most men, depending on weight).
Trials are being conducted to determine the authenticity of consuming Indole-3-Carbinol supplements to prevent illnesses, particularly cancer. Although it does not provide an active cure to cancer, Indole-3-Carbinol is scientifically proven to support the health of reproductive organs and cellular reproduction for both men and women. It also assists in detoxifying the intestines and liver. As an antioxidant, it stimulates the production of enzymes that detoxify toxins and protects cell structures including DNA. Lycopene is another vegetable antioxidant with proven health benefits.With possible anti-carcinogenic, antioxidant and anti-anthropogenic effects, this vegetable component is only just being acknowledged as a solution to a variety of health issues Indole-3-Carbinol is currently being clinically researched as a cancer preventive agent by the National Institutes of Health.
Other names for Indole-3-Carbinol:
I3C, 3-Indolylcarbinol, 1H-Indole-3-methanol, 3-Hydroxymethyl Indole, 3 Hydroxymethyl Indole, I3C, Indole 3 Carbinol, 3-(hydroxymethyl), 3-(hydroxyméthyl), 3 (hydroxymethyl) Indole, 3 Indolylcarbinol, 3-Indolylmethanol, 3 Indolylmethanol, Indol-3-Carbinol, Indole, Indole 3 Carbinol, Indole-3-methanol, Indole-3-méthanol.